Methadone, and make the United States, is also a kind of synthetic narcotics. Its hydrochloride is colorless or white crystalline powder, odorless, bitter taste, dissolving in water and common dosage forms are capsule, oral use. Methadone is clinically used as analgesic drug, slightly stronger than the analgesic effects of morphine, toxicity and less side effects, methadone can instead of morphine and heroin detoxification etc.
Because the methadone is a kind of typical u – agonists, can control of opioid withdrawal symptoms.
After methadone oral absorbed completely, after the absorption and plasma protein level (85%), mainly in lung, liver, kidney and spleen. Bioavailability of methadone is high (90%), gastrointestinal drug delivery in 3 hours of blood concentration peak, peak concentration can maintain blood 2-6 hours. Methadone has a half-life of 15 hours, oral can effectively inhibit withdrawal symptoms after 24, 32 hours. Methadone treatment the blood concentration of o. 48 a o. 86 mg/L, poisoned blood drug concentration for 2 mg/L, lethal blood levels of > 4 mg/L. The liver is the main place to methadone metabolism, from the eduction in urine and stool without changing the dosage is less than, 10% of clothing into the traffic.
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